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Several RNAi drugs, including aptamers like pegaptanib targeting protein targets, and micro interfering RNAs like givosiran and patisiran, as well as antisense oligonucleotides like golodirsen and inotersen that interfere directly with RNA targets, have received FDA approval for medical use (Yu et al., 2020)
Many patients find they have more energy and endurance after a few weeks on AOD-9604, at which point gradually increasing exercise intensity makes sense
doi: 10.1007/s00415-003-1161-6
