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In both obese and nonobese subjects, fasting and weight reduction cause a significant enhancement of sensitivity to the antilipolytic effects of insulin (7, 28, 71)
Berberine , a plant alkaloid that lowers blood glucose and cholesterol through AMPK and is often called natures metformin, has no clinical evidence for cognition or neuroprotection, only animal work
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As such, these findings may not fully translate to real-world conditions, where many individuals with cognitive decline face challenges such as limited digital literacy, physical or sensory impairments, and socioeconomic barriers
