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Interestingly, leptin-deficient obese mice or diet-induced obese mice present increased levels of CB1 and DAGL in the lateral hypothalamus (Cristino et al., 2013), evidencing an inverse relationship between leptin and ECS signaling

5.2 Risk of Adverse Reactions or Loss of Virologic Response Due to Drug Interactions The concomitant use of GENVOYA and other drugs may result in known or potentially significant drug interactions, some of which may lead to [see Contraindications (4) and Drug Interactions (7.5)]: Loss of therapeutic effect of GENVOYA and possible development of resistance

Endocrinologia y Nutricion (in Spanish)