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[71] reported that cafestol has neuroprotective effects in Drosophila models of PD, which activates the NRF2/antioxidant response element pathway, increases the expression of HO-1, eliminates excessive ROS production, protects against oxidative DNA damage, and upregulates glutathione [71,72]

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In recent years, a large number of studies have demonstrated that different types of cell death (including apoptosis, pyroptosis, necroptosis, and ferroptosis) occur concurrently in the progression of NAFL to NASH and that their occurrence correlates with the severity of the disease

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