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Total glutathione measured in heart and liver tissues of WT and HO Chac1 E116A knock-in mice

Although micronutrients are needed in small amounts, they are essential to life activity and homeostasis

Take Vitamin C (5001000 mg daily) for better absorption Stay hydrated (23 liters of water daily) Avoid smoking, alcohol, and stress (they deplete glutathione) Use sunscreen and limit sun exposure Eat antioxidant-rich foods (fruits, vegetables, nuts) Are glutathione tablets safe for long-term use

However, their activity decreases with aging, creating an imbalance between oxidative damage and repair mechanisms.12 Excessive accumulation of reactive oxygen species (ROS) within hair follicle melanocytes leads to cellular damage through lipid peroxidation, DNA strand breaks, mutations, and protein and enzyme denaturation