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Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

These side effects are generally very limited and tend to go away rapidly

When your reserves of B12 are low or exhausted, you can easily experience: Failing dental health Bleeding gums Sores in your mouth Diminished or non-existent appetite Digestive problems including constipation, nausea, diarrhea, and/or stomach cramping Experiencing any one symptom can really throw a wrench into the works of your life, but often a person with a vitamin B12 deficiency will experience multiple symptoms at once

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