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These substitutes may be more dependence forming (such as methamphetamine), or more prone to induce overdose (such as methaqualone at grossly elevated dosages) or having properties seemingly antagonistic to those of MDMA (such as ketamine)

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Glycine regulates protein turnover by activating protein kinase B/mammalian target of rapamycin and by inhibiting MuRF1 and atrogin-1 gene expression in C2C12 myoblasts
