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151 Therapy for eDKA is very similar to that for cats on insulin who develop DKA, with a few caveats (Figure 18): SGLT2is should be discontinued immediately

Experimental evidence includes: GPX4-knockout mice show 3-fold larger infarcts with lipid peroxide accumulation in high-OXPHOS regions, while ferroptosis inhibitors (e.g., ferrostatin-1) reduce neuronal loss by 60% in MCAO models [163, 165]

The antioxidants ALC and NAC are well known for their neuroprotective effects and they can both enhance neuronal biosynthesis of glutathione which is the principal renewable free radical scavenger within neurons [11], [20], [22], [44]
Leehey et al
