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Peripheral LEAP-2 administration blunted ghrelin-induced food intake only when the dose was 3-fold (19), 10-fold (7), and 20-fold (5) higher than peripheral ghrelin dose, and failed to inhibit the orexigenic effect of ghrelin when given equivalent doses (5)

A controlled Phase III trial of dichloroacetate in children with pyruvate dehydrogenase complex deficiency (ClinicalTrials.gov ID#: NCT02616484), using a validated parental observation of child behavior scale as the primary outcome measure is undergoing result analysis and FDA review

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Sterile saline (0.9% sodium chloride) is sometimes used, but it can cause certain peptides to aggregate or 'clump' over time, affecting solubility and potency