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Residues 14 were disordered in all structures along with loop residues 133135 in C1-31

26,27 Upon exposure to xenobiotics, Nrf2 dissociates from Keap1 and translocates into the nucleus where it heterodimerizes with other leucine zipper proteins such as Maf or other partners and binds to a cis -acting deoxyribonucleic acid (DNA) regulatory element, namely the antioxidant response element (ARE) in the upstream promoter region, and initiates the transcription of a wide array of cytoprotective target genes that participate in xenobiotic disposition and clearance from the body and maintain essential cellular defensive functions against myriad toxic products, including metalloids, chemical carcinogens, and radiation

Improving Quality of Life The primary aim of IV iron therapy is to enhance the quality of life for individuals with low iron levels