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10.1016/j.pbb.2017.08.012
Melatonin biosynthesis is enzymatically transformed, non-enzymatically or pseudo-enzymatically into numerous active metabolites such as AFMK (N1-acetyl-N2-formyl-5-methoxykynuramine), 5-MT (5-methoxytrayptamine), C3HMO (cyclic 3-hydroxymelatonin) and AMK N1-acetyl-5-methokynuramine (175)

These diabetes-specific results mirror the pattern seen with CagriSema in REDEFINE 2, though direct comparison requires caution because the trial populations and designs differed
Secondary outcomes included ADAS-Cog (400 g arm), MMSE, ADCS-Clinical Global Impression of Change (CGIC), ADCS-Activities of Daily Living (ADL), and Neuropsychiatric Inventory (NPI) [60]
