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Strikingly, deficiency in a single amino acid transporter, SLC7A5, is sufficient to phenocopy the effects of MYC deficiency, preventing most T cell growth and protein synthesis [3]
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The intracellular glutamate concentration is 10-fold higher than the K m value but cysteine concentration approximates the apparent K m value [47]
Borsting E, Cheng VP, Glass CK, Vallon V, Cunard R
