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The most frequent location for pigmented lesions in males was the glans penis (19 patients, 67.9%), followed by the meatus (6 patients, 21.4%), and the shaft of the penis (3 patients, 10.7%)

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in 2005 (18), and Kaehler et al

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For example, inhibitors such as compound A blocks substrate SKP2 binding to the SCF complex, and agonists, such as thalidomide, primarily target cereblon (CRBN), a substrate-recognizing subunit of the CUL4-DDB1 E3 Ub ligase complex ( Table 1 )

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