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Description
There is a long extracellular loop consisting of 107 amino acids between the first two transmembrane domains, which is highly conserved among organic cation transporters encoded by members of the solute carrier (SLC) 22 family, suggesting an essential role in transporter function [92]
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The rationale: once hepatic steatosis resolves and dietary methyl intake stabilizes, endogenous methylation capacity can maintain phosphatidylcholine synthesis without weekly exogenous supplementation
