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doi: 10.1134/S1990519X07010063

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PRRX2 promotes GSC maintenance [53] while GCH1-derived tetrahydrobiopterin (BH4) exerts antioxidant effects through lipid remodeling [54, 55]

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Although so far no licensed drug therapy for NASH exists, they can be used alone or in combination with vitamin E according to current treatment guidelines.125 153 Glitazones also have shown beneficial effects in preclinical models of cholestasis by inhibiting bile duct proliferation and fibrosis in a rat model of chronic cholestasis154 but these have clinically never been followed systematically except single case reports.155 In contrast to PPAR a direct role for PPAR in the regulation of BA metabolism has not yet been reported

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Liu Y, Wang DW, Wang D, Duan BH, Kuang HY

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