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3) You mentioned that your dad has a kidney transplant 1.5 years ago
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And they diminish substantially after 8-12 weeks on a stable dose
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To address these clinical impediments, second and third-generation platinum (Pt) drugs, mainly cis -diammine(1,1-cyclobutanedicarboxylato)platinum(II) (carboplatin) and trans -L-(1 R ,2 R -diaminocyclohexane)oxalatoplatinum(II) (oxaliplatin), were developed [16]
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