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The presence of a lot of Co in the diet can cause rumen microbes to create more vitamin B12 analogs than cobalamin, the former of which are utterly useless to the bovine

10.1007/s10557-008-6132-9
What inclusion on the 503A Bulks List actually authorizes Inclusion on the 503A Bulks List means FDA has determined, through formal rulemaking, that a bulk drug substance may be used in 503A patient-specific compounding