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A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1E9 mouse model of Alzheimers disease

S4D showing the knockdown efficiency and Supplementary Fig

Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants

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