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ROS production from XOR is implicated in several pathological conditions, including heart failure 75

J Endocrinol (2014) 221:R3140

Moreover, previous studies demonstrate that IGF promotes mitochondrial biogenesis and turnover in cancer cells by inducing peroxisome proliferator-activated receptor coactivator 1 (PGC-1), PGC-1-related coactivator, nuclear factor-erythroid-derived 2-like 2 (NFE2L2/NRF2), and the mitophagy mediator BNIP3 [63]
