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However, reliable and precise diagnostic and prognostic biomarkers for PF are still lacking

Fumagillin and its synthetic analogue TNP-470 are both irreversible binders of the methionine aminopeptidase-2 (MetAP-2) and prevent the advancement of endothelial cell cycles and neovascularization [279, 306]

The studies have suggested that in comparison with rodents, relatively little AFB1-GSH conjugate is produced by human liver, but insufficient data exist to be certain that this reaction is not of physiological importance in man, particularly as an aflatoxin mercapturate has been detected in the urine of marmoset monkeys treated with AFB 1

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