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doi: 10.13880/j.cnki.65-1174/n.2014.03.004 36 LivakK

Some may cross the blood-brain barrier by the paracellular route, by transcytotic mechanisms, inside entering monocytes (the Trojan horse hypothesis), or by other mechanisms, such as hijacking of -adrenergic receptors, as done for example by N

Key Takeaways Magnesium is essential for glutathione production: It activates key enzymes that help create and recycle glutathione, the bodys master antioxidant

Lipid hydroperoxides, generated primarily through the activity of lipoxygenases (LOXs), are key mediators of cellular dysfunction and death ( 2.1.3 Antioxidant system 2.1.3.1 System Xc-/GSH/GPX4 axis The cystine/glutamate antiporter (System Xc-), glutathione (GSH), and glutathione peroxidase 4 (GPX4) form a critical antioxidant axis that plays a central role in regulating ferroptosis