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Preclinical evidence demonstrates that several natural and synthetic peptidessuch as biphalin, LPF-35, neurotensin, or ARA 290, can simultaneously modulate nociceptive pathways and accelerate tissue repair

It is important to emphasize that although the events reported occurred during treatment with clomipramine, they were not necessarily caused by it

Wound-related pain can be categorized into several clinically relevant types: Background or baseline paincaused by the underlying pathology and the wound itself, representing discomfort experienced during routine daily activities