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An imbalance between the prooxidant and antioxidant links of this system leads to hyperproduction of oxygen radicals and damage to cells and tissues [6]

10.1016/j.freeradbiomed.2015.05.041 Free Radic Biol Med

17 The degradation of the proteoglycan aggregates and generation of a large quantity of non-aggregating proteoglycans is thought to be a precursor to disc degeneration

10.1016/0891-5849(87)90009-8 69 NavasP.VillalbaJ
