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N-Acetylcysteine alleviates depressive-like behaviors in adolescent EAAC1(-/-) mice and early life stress model rats

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J Psychiatry Neurosci 35:5962

Macrophage/foam cell-released proteolytic enzymes (matrix metalloproteinases, MMPs) allows for smooth muscle cells from the adjacent media to migrate into the intima, proliferate and secrete fibrous connective tissue (i.e., collagen) and extracellular matrix (smooth muscle cells change their phenotype from contractile to synthetic cells)