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Berberine improves cognitive impairment by simultaneously impacting cerebral blood flow and -Amyloid accumulation in an app/tau/ps1 mouse model of Alzheimers disease

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4,5,6,7-tetrabromo-2-azabenzamidazole (TBB), which specifically inhibits casein kinase 2 (CK2), was selected and discovered to preferentially trigger apoptosis in Zmpste24 / cells
