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(2021) demonstrated that escalating doses were well-tolerated in humans with no dose-limiting toxicities
GT and RC equally contributed to the work by performing all the experiments
They bind to complementary target messenger RNA (mRNA) predominantly in the 3-untranslated region, leading either to its degradation or to inhibition of protein synthesis, depending on the degree of sequence complementarity between the miRNA and the mRNA [282]
While every treatment has benefits, it may have unintended side effects (Barazzuol et al
