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Chelating agents like EDTA and EGTA act by binding calcium ions that maintain tight junction integrity, thereby transiently increasing intestinal paracellular permeability, their use in oral insulin formulations highlights their clinical relevance [96]
Meng Z, Kay Garcia M, Hu C, Chiang J, Chambers M, Rosenthal DI , Peng H, Wu C, Zhao Q, Zhao G, Liu L, Spelman A, Lynn Palmer J, Wei Q, Cohen L

D'Ascanio AM, Mullally JA, Frishman WH
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