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Impaired neurotransmission, immune dysregulation in the brain, mitochondrial dysfunction, and a mix of environmental factors may also contribute to treatment response
7, 693698.10.1038/89068 33 DurandE.Al Haj ZenA.AddadF.BrasseletC.CaligiuriG.VinchonF.LemarchandP.DesnosM.BrunevalP.LafontA
However, the duration of the hormone signal is short, as cAMP is quickly deactivated by the enzyme phosphodiesterase (PDE) , which is located in the cytosol