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For example, NAD+-dependent enzymes include the sirtuins (SIRT1-7), a family of protein deacetylases involved in gene expression, stress responses, and metabolic regulation, as well as poly(ADP-ribose) polymerases (PARPs) that assist in DNA repair
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During this process, NH 3 is released and the lipoyl group of the H protein becomes reduced (dihydrolipoyl form)
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