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For example, female mice with IGF-1R knock-out were shown to be completely sterile, with no antral follicles and a 90% reduction in serum E2 levels (66)

Lancet 395:10541062

(PubMed) Lo RY, Figueroa KP, Pulst SM, et al

The World Alzheimer Report (2021) estimates that over 55 million individuals live with dementia (4)
