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FIGURE 2 Next, we evaluated the impact of various side chains at the -4 position of CBD on its antiproliferative effect
Trx-(SH)2 and GSH then supply reducing equivalents for a number of different reactions, including those that are glutaredoxin (Grx)-dependent
However, clinical use has been challenging due to poor bioavailability and ineffective delivery [95]
Collectively, these studies describe a mechanism by which glutamine-derived nitrogen is essential for the rapid proliferation of cancer cells corresponding to an urgent need for nucleotide biosynthesis
