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Oxidative stress imposes secondary damage on both mitochondria and macromolecules (such as mtDNA, ETC proteins and lipids), thereby significantly impairing energy generation (120)

Age of donors varied between 18 and 70 years

doi: 10.1080/09513590600906607 3 BaillyC

Consistent with reduced inflammation, aged Mx1-T3 mice displayed lower circulating inflammatory cytokine concentrations (Fig

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