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Whilst vitamin B12 toxicity is exceptionally rare, very high levels from supplements or injections have been associated with skin reactions such as acne-like eruptions

doi: 10.3390/nu9050521 181 Rodrguez-DazaMCPulido-MateosECLupien-MeilleurJGuyonnetDDesjardinsYRoyD

Vitamin B12 is reduced to cobalamin regardless of form (cyan-, methyl-, adenosyl-, hydroxo-) then re-assembled as methylcoblamin by MS for use in the cytosol, or adenosylcobalamin by MM for use in the mitochondria
