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3f), the persister cell sensitivity to disulfiram may be reflective of the broader disabled antioxidant program
National Library of Medicine clinical trials database
Agents that conjugate to glutathione, such as APR-246, as well as chemical or genetic inhibition of glutathione biosynthesis, disrupt tumor cell growth and induce a ferroptosis-like form of cell death (Liu et al., 2017)
Homocysteine is a well-known redox perturbant and hyperhomocystenemia is known to be associated with redox stress in eukaryotes
