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After incubation at 37C for 2 h, 100 l of the supernatant was collected for ultrahigh performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) analysis of the specific metabolites of the six CYP variants: acetaminophen (CYP1A), OH-bupropion (CYP2B6), 4-OH-mephenytoin (CYP2C19), 4-OH-diclofenac (CYP2C9), OH-bufuralol (CYP2D6) and 1-OH-midazolam (CYP3A)

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An insufficient blood supply to the optic nerve, either due to increased IOP or other vascular risk factors that may reduce ocular blood flow, will induce ischemia and hypoxia processes in the RGCs and their axons, contributing to the development of glaucomatous pathology ( There are several indications postulating that reduced blood flow is one of the causes of glaucomatous pathology

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115 Low maternal serum vitamin D levels also increase the risk of depression during pregnancythought to affect 10%-20% of women in high-income countries 116 with a subsequent increased risk of postpartum depression

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