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Acknowledgements We thank the graphic design service of the CHU de Qubec-Universit Laval Research Centre for the formatting of the figures

To avoid irritation and protect surrounding skin: Apply a thin layer of the cream directly to areas with freckles on clean, dry skin Avoid applying it to the entire face unless instructed, especially if you have sensitive skin Use the treatment at night or as directed by your dermatologist Always follow with SPF 30+ sunscreen during the day, as lightening agents can increase UV sensitivity Most treatments require 8 to 12 weeks of regular use before visible improvement