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This integrated tri-agonist approach produces synergistic metabolic effects that cannot be achieved with other research peptides: Source: Jastreboff et al., New England Journal of Medicine, 2023 Source: Killion et al., Nature Metabolism, 2022 Source: U.S

358 Similarly, administration of metformin in cerebral ischemic stroke models alleviated oxidative stress-induced BBB damage, possibly through activation of the NRF2/ARE signaling pathway