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Concurrently, non-genomic signaling via GPER rapidly activates secondary messengers like cAMP and Ca 2+ , further modulating melanogenic activity and melanocyte proliferation

doi: 10.1186/s13073-021-00933-8 57 FunahashiJ.SekidoR.MuraiK.KamachiY.KondohH

However, it has been proposed that activation of this common pathway through physiological signals results in term labor, while preterm labor might occur from spontaneous activation of isolated aspects of the common pathway by the presence of pathological conditions that may be induced by multiple causes [238] or risk factors

Leaky gut is closely linked to autoimmunity and plays a big role in Hashimoto's