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One patient, who was lost to follow-up after undergoing randomization to the sofosbuvir-velpatasvir group but before receiving treatment, was excluded from the safety and efficacy analyses

Other possible mechanisms to improve insulin sensitivity in NAFLD reported in the literature include the regulation of the acetyl-CoA/CoA ratio in mitochondria, modulation of the pyruvate dehydrogenase complex (PDHC) activity, altering the expression of glycolytic and gluconeogenic enzymes as well as the expression of genes associated with the insulin signaling cascade, and stimulation of the insulin-like growth factor-1 (IGF-1) axis and IGF-1 signaling cascade (55)

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Inadequate sleep can disrupt hormones that regulate hunger and fullness (ghrelin and leptin), increasing your appetite