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Description
9193 Studies show a decreased ability in children with these genetic variants to handle oxidative stress as measured by several metabolic biomarkers including S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), adenosine, homocysteine, cystathionine, cysteine, oxidized and reduced glutathione, endogenous secretory receptor for advanced glycation end-products (RAGE), and the pro-inflammatory ligand S100A9

doi: 10.1056/NEJMoa2004407

Regul Pept (1990) 28:5769

A therapeutic index (T.I.) was calculated as follows: [EC 50 for MetHb formation]/[EC 50 for parasite growth inhibition]
