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Physiologically, and similar to apoptosis of nucleated cells, eryptosis occurs to ultimately eliminate damaged senescent, and damaged or dysfunctional mature erythrocytes from the circulation [204]

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In another series of experiments, Nrf2 (/) knockout rats in the Sprague-Dawley genetic background [42] and wild type littermates were fed either high (HS) salt diet (4.0% NaCl), or a high salt diet fortified with Protandim (4.0% NaCl + ~60 mg/kg/day Protandim) for 1014 days