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2024 Dec 20;55(1):172

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This reduced pain sensation with caffeine is thought to allow athletes to exert themselves harder and for longer in training or competition, and a greater willingness to tolerate the discomfort of exercise

Oxidative stress and hypoxia-induced RPE cell death have long been considered to play crucial roles in the initiation and progression of AMD, and ferroptosis was identified as one of the main cell death mechanisms of oxidative stress (Henning et al., 2022
