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While, down-regulation of the transporter directly confers resistance against the drug, via decreasing the intracellular platinum concentration (Kunii et al., 2015)

The study of natural mutations [3] and chimeric transporters obtained by fusing specific domains of the OCTN2 transporter with the organic cation transporter novel 1 (OCTN1, SLC22A4 , that does not transport carnitine) [98] has identified multiple domains of OCTN2 essential for function

References Papers of particular interest, published recently, have been highlighted as: Of major importance Grochowski C, Blicharska E, Baj J, Mierzwinska A, Brzozowska K, Forma A, et al

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