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Drug/Laboratory Test Interactions Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B 12diagnostic blood assays

FDA-NIH biomarker working group, BEST (Biomarkers, EndpointS, and other Tools) resource, Silver Spring (MD): Food and Drug Administration

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The recommendation here is to start at the lower end of the dosing range, specifically 750 mcg three times per week, before escalating to a standard or aggressive protocol