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The binding of 4-HNE to the MCU leads to the formation of higher order MCU oligomers, thus enhancing Ca 2+ entry and causing mitochondrial Ca 2+ overload
If glutathione is depleted by an excessive intake of acetimenophen, NAPQI accumulates and interacts with various macromolecules, leading to hepatocyte injury and potentially death from fulminant liver failure
However, some diseases, vitamin deficiency, exposure to tobacco smoke, alcohol, and drugs may upset the balance between detoxification enzymes
doi: 10.1016/j.bbrc.2024.149788 30 ZhaoYZhengGYangSLiuSWuYMiaoYet al
