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It is difficult to judge for sure whether the early drastic decrease in Plp- and Mog- positive cells implies a drastic death/loss of the mature OLs or just an extreme-down regulation of the expression of these myelin-associated genes by the OLs while they themselves are still alive

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Research published in Frontiers in Pharmacology demonstrated that Selank influences the expression of genes involved in GABAergic neurotransmission

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