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doi: 10.1161/HYPERTENSIONAHA.111.169748 132

Activation of FXR affects hepatitis B virus DNA replication as well as prevents hepatocarcinogenesis by regulating the NF-B signaling pathway to inhibit the injury caused by the persistent immune response and cytotoxicity induced by the virus products and accumulation of toxic bile acids 47

On the other hand, deletion of SlNCED1, a key regulatory enzyme of ABA biosynthesis, blocks the changes in tomato fruit texture that occur during ripening by downregulating the expression of genes associated with cell wall metabolism (Sun et al., 2012)

For the molecular and metabolic experiments, T2 homozygous plants were used