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7 Therapeutic approaches to mitigate BBB dysfunction and cognitive decline Intestinal ischemiareperfusion (I/R) injury and the resulting systemic inflammation can severely compromise the bloodbrain barrier (BBB), leading to cognitive dysfunction (Zhang et al., 2024b)

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doi: 10.3389/fimmu.2024.1422940 Received 24 April 2024 Accepted 25 June 2024 Published 09 July 2024 Volume 15 - 2024 Edited by Lucia Mundo, University of Limerick, Ireland Reviewed by Mark Daniel Hicar, University at Buffalo, United States Egidia Miftode, Grigore T

A dark place is also critical, as UV light can be just as damaging as heat