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doi: 10.1146/annurev.Pharmtox.45.120403.095857
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The association between smoking and MASLD is underpinned by shared pathological mechanisms, particularly insulin resistance and visceral fat accumulation, which are central to the metabolic syndrome (MetS)
The foundational mechanism underpinning these effects is the production of neuroactive metabolites by gut bacteria, which bear structural and functional resemblance to host-derived neurochemicals (448)
