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Treatment should only be initiated if other treatments are ineffective or not tolerated and the benefit and risk should be carefully reconsidered at regular treatment reviews

Functional effects of carnitine and acylcarnitine Both carnitine and acylcarnitine are essential for intracellular energy metabolism, and their physiological roles include the following: (1) Carnitine serves as the sole carrier of long-chain fatty acids, which are transferred to the cellular mitochondria for -oxidation

Thus, AR dimerization utilized tunable surfaces that are important for interdomain allostery and were found to be particularly important to bind degenerate DNA sequences, providing an explanation for how AREs that deviate considerably from the optimal textbook sequence in CaP still lead to robust transcriptional outputs

Cell Metab (2019) 29:6477.e66